Zfp423^tm1Reed
Targeted Allele Detail

Summary

• Symbol: Zfp423^tm1Reed
• Name: zinc finger protein 423; targeted mutation 1, Randall R Reed
• MGI ID: MGI:3714340
• Synonyms: Oaz^-
• Gene: Zfp423 Location: Chr8:88388438-88686223 bp, - strand Genetic Position: Chr8, 42.29 cM, cytoband C4
• Alliance: Zfp423^tm1Reed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122275
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert an IRES-YFP-polyA cassette followed by a loxP-TK(delta)-neo-loxP cassette 55 nucleotides downstream of exon 4 splicing acceptor, thereby eliminating the remainder of the ORF. The floxed neo was subsequently removed by crossing with mice expressing cre recombinase in the germline. (J:122275)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp423 Mutation: 274 strains or lines available

References

• Original: J:122275 Cheng LE, et al., Zfp423/OAZ participates in a developmental switch during olfactory neurogenesis. Neuron. 2007 May 24;54(4):547-57
• All: 3 reference(s)