Itga11^tm1Dgul
Targeted Allele Detail

Summary

• Symbol: Itga11^tm1Dgul
• Name: integrin alpha 11; targeted mutation 1, Donald Gullberg
• MGI ID: MGI:3714472
• Synonyms: alpha11^-, integrin alpha11^-
• Gene: Itga11 Location: Chr9:62585108-62691264 bp, + strand Genetic Position: Chr9, 33.82 cM
• Alliance: Itga11^tm1Dgul page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122349
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A construct containing IRES-lacZ-polyA-loxP-polyA-neo-pgk-loxP was inserted into exon 3. RT-PCR confirmed absence of transcript from exons 3 and beyond in mutants. The neo was subsequently removed by crossing with mice expressing cre recombinase in the germline. (J:122349)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Itga11 Mutation: 77 strains or lines available

References

• Original: J:122349 Popova SN, et al., Alpha11 beta1 integrin-dependent regulation of periodontal ligament function in the erupting mouse incisor. Mol Cell Biol. 2007 Jun;27(12):4306-16
• All: 11 reference(s)