Dp(16Lipi-Zbtb21)1Yey
Targeted Allele Detail

Summary

• Symbol: Dp(16Lipi-Zbtb21)1Yey
• Name: duplication, Chr 16, Y Eugene Yu 1
• MGI ID: MGI:3714529
• Synonyms: Dp16, Dp(16)1/Yey, Dp(16)1Yey, Dp(16)1Yu, Dp(16D930038D03Tik-Zfp295)1Yey, Dp(16Lipi-Zfp295)1Yey, Dp1Yu, Ts1Yey
• Gene: Dp(16Lipi-Zbtb21)1Yey Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121790
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Duplication
• Dp(16Lipi-Zbtb21)1Yey involves 37 genes/genome features (Gm26170, Gm26219, Gm15954 ...) View all
• Mutation details: A 22.9Mb region of chromosome 16 that is syntenic with human chromosome 21 was duplicated using a Cre/loxP-mediated recombination system. This region, thought to be involved in Down Syndrome, contains 113 orthologues including all markers between and including D930038D03Rik (Lipi) and Zfp295 (Zbtb21). (J:121790)

Disease models

Expression

In Mice Carrying this Mutation:

14 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Dp(16Lipi-Zbtb21)1Yey Mutation: 3 strains or lines available

References

• Original: J:121790 Li Z, et al., Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities. Hum Mol Genet. 2007 Jun 1;16(11):1359-66
• All: 75 reference(s)