Wasf1^tm2Jsco
Targeted Allele Detail

Summary

• Symbol: Wasf1^tm2Jsco
• Name: WASP family, member 1; targeted mutation 2, John D Scott
• MGI ID: MGI:3714530
• Synonyms: wave ^m
• Gene: Wasf1 Location: Chr10:40759476-40814565 bp, + strand Genetic Position: Chr10, 22.07 cM
• Alliance: Wasf1^tm2Jsco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117303
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to place a neomycin cassette in intron 6, and delete amino acids 322-332 and 425-431 of exon 7. Protein levels are similar to wild-type as shown by immunoprecipitation, but the level of protein binding to Rac GTPase-activating protein (WRP) is reduced by 50%. (J:117303)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wasf1 Mutation: 50 strains or lines available

Notes

ES cell line = JSI-1.

References

• Original: J:117303 Soderling SH, et al., A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. J Neurosci. 2007 Jan 10;27(2):355-65
• All: 1 reference(s)