Lepr^db-lb
Spontaneous Allele Detail

Summary

• Symbol: Lepr^db-lb
• Name: leptin receptor; pound
• MGI ID: MGI:3714780
• Synonyms: Lepr^db-lb, pound
• Gene: Lepr Location: Chr4:101574601-101672549 bp, + strand Genetic Position: Chr4, 46.96 cM
• Alliance: Lepr^db-lb page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Spontaneous
• Mutations: Intragenic deletion, Inversion
• Mutation details: This mutation resulted from a spontaneous deletion/inversion event that removed exon 2, containing the initiation codon, from the leptin receptor gene. Splicing of the mutant transcript joins exon 1 to exon 3. While there is an initiation codon in exon 3, it is not in frame and its use leads to immediate termination of translation. (J:171755)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lepr Mutation: 122 strains or lines available

References

• Original: J:171755 Baldwin W, et al., Hyperuricemia as a mediator of the proinflammatory endocrine imbalance in the adipose tissue in a murine model of the metabolic syndrome. Diabetes. 2011 Apr;60(4):1258-69
• All: 1 reference(s)