Pkd1^tm1Bdgz
Targeted Allele Detail

Summary

• Symbol: Pkd1^tm1Bdgz
• Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, William Dackowski
• MGI ID: MGI:3714781
• Synonyms: Pkd1^tm1Bdgz -
• Gene: Pkd1 Location: Chr17:24768808-24815482 bp, + strand Genetic Position: Chr17, 12.4 cM
• Alliance: Pkd1^tm1Bdgz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130086
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Inversion
• Mutation details: The mutation is an inverted duplication of exons 12-15 in intron 26, followed by a duplication of exons 17-26. (J:130086)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkd1 Mutation: 154 strains or lines available

References

• Original: J:130086 Natoli TA, et al., Pkd1 and Nek8 mutations affect cell-cell adhesion and cilia in cysts formed in kidney organ cultures. Am J Physiol Renal Physiol. 2008 Jan;294(1):F73-83
• All: 1 reference(s)