Lmx1b^tm4.1Rjo
Targeted Allele Detail

Summary

• Symbol: Lmx1b^tm4.1Rjo
• Name: LIM homeobox transcription factor 1 beta; targeted mutation 4.1, Randy L Johnson
• MGI ID: MGI:3714802
• Synonyms: Lmx1b^tm1Witz, Lmxb1^lox
• Gene: Lmx1b Location: Chr2:33450977-33530620 bp, - strand Genetic Position: Chr2, 22.48 cM
• Alliance: Lmx1b^tm4.1Rjo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122505
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted into introns 4 and 6, flanking sequence that encodes the homeodomain. The construct also contains a loxP-flanked neomycin selection cassette. A Cre expression plasmid was used to remove the floxed neo cassette. (J:122505)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lmx1b Mutation: 16 strains or lines available

References

• Original: J:122505 Suleiman H, et al., The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes. Dev Biol. 2007 Apr 15;304(2):701-12
• All: 7 reference(s)