Ubc^tm1Rrk
Targeted Allele Detail

Summary

• Symbol: Ubc^tm1Rrk
• Name: ubiquitin C; targeted mutation 1, Ron R Kopito
• MGI ID: MGI:3715099
• Synonyms: UbC^-, UbC^GFP-Puro, Ubc^{Gt(GFP-Puro)1Rrk}, Ubc^tm11Rrk
• Gene: Ubc Location: Chr5:125463029-125467081 bp, - strand Genetic Position: Chr5, 64.18 cM
• Alliance: Ubc^tm1Rrk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122574
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed GFP and puro cassette is used to replace the entire coding region creating a null allele. This cassette can be removed with Cre recombination without any effect. (J:122574)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ubc Mutation: 5 strains or lines available

References

• Original: J:122574 Ryu KY, et al., The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. EMBO J. 2007 Jun 6;26(11):2693-706
• All: 5 reference(s)