Sun1^tm1Mhan
Targeted Allele Detail

Summary

• Symbol: Sun1^tm1Mhan
• Name: Sad1 and UNC84 domain containing 1; targeted mutation 1, Min Han
• MGI ID: MGI:3715140
• Synonyms: Sun1^-, Sun1^{(delta ex10-13)}
• Gene: Sun1 Location: Chr5:139186392-139235595 bp, + strand Genetic Position: Chr5, 78.12 cM, cytoband G1
• Alliance: Sun1^tm1Mhan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122602
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons encoding all three putative transmembrane domains of SUN1 (exons 10-13) were replaced by a neomycin resistance gene. RT-PCR confirmed absence of normal mRNA transcripts in mutant testis and muscle. (J:122602)

Expression

In Mice Carrying this Mutation:	21 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sun1 Mutation: 64 strains or lines available

References

• Original: J:122602 Ding X, et al., SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Dev Cell. 2007 Jun;12(6):863-72
• All: 18 reference(s)