Pfn2^tm1Wit
Targeted Allele Detail

Summary

• Symbol: Pfn2^tm1Wit
• Name: profilin 2; targeted mutation 1, Walter Witke
• MGI ID: MGI:3715145
• Synonyms: pfn2^-
• Gene: Pfn2 Location: Chr3:57749316-57755178 bp, - strand Genetic Position: Chr3, 28.15 cM
• Alliance: Pfn2^tm1Wit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122603
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The beta-geo cassette was inserted into exon 3, thereby disrupting the reading frame. Western blot confirmed absence of protein in brain lysates from mutant mice. (J:122603)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pfn2 Mutation: 7 strains or lines available

References

• Original: J:122603 Pilo Boyl P, et al., Profilin2 contributes to synaptic vesicle exocytosis, neuronal excitability, and novelty-seeking behavior. EMBO J. 2007 Jun 20;26(12):2991-3002
• All: 4 reference(s)