Hand2^tm1Cse
Targeted Allele Detail

Summary

• Symbol: Hand2^tm1Cse
• Name: heart and neural crest derivatives expressed 2; targeted mutation 1, Peter Cserjesi
• MGI ID: MGI:3715149
• Synonyms: Hand2^2F, Hand2^loxP
• Gene: Hand2 Location: Chr8:57774018-57777552 bp, + strand Genetic Position: Chr8, 29.8 cM
• Alliance: Hand2^tm1Cse page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122604
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank the exon. A frt-flanked neo was included upstream of the 3' loxP site. Frt-mediated recombination removed the neo, leaving the single exon floxed. (J:122604)

Expression

In Mice Carrying this Mutation:	38 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hand2 Mutation: 12 strains or lines available

References

• Original: J:122604 Morikawa Y, et al., Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system. Dev Biol. 2007 Jul 1;307(1):114-26
• All: 14 reference(s)