Pdyn^tm1(cre)Czer
Targeted Allele Detail

Summary

• Symbol: Pdyn^tm1(cre)Czer
• Name: prodynorphin; targeted mutation 1, Christoph Schwarzer
• MGI ID: MGI:3715202
• Synonyms: Dyn^-
• Gene: Pdyn Location: Chr2:129528485-129541764 bp, - strand Genetic Position: Chr2, 63.19 cM
• Alliance: Pdyn^tm1(cre)Czer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122651
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Pdyn^tm1(cre)Czer expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pdyn (MGI:97535)

• Mutation details: The coding sequence for the transactivator of the Tet-on system (rTetR) was introduced directly after the ATG, disrupting the coding sequence. The transactivator responsive element (TRE) was placed in the reverse orientation, driving cre expression. Floxed neomycin and zeocin resistance genes were included in the vector, also in reverse orientation. (J:122651)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pdyn (mouse) Summary of all recombinase alleles driven by Pdyn. Alliance mouse Pdyn gene page

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdyn Mutation: 20 strains or lines available

References

• Original: J:122651 Loacker S, et al., Endogenous dynorphin in epileptogenesis and epilepsy: anticonvulsant net effect via kappa opioid receptors. Brain. 2007 Apr;130(Pt 4):1017-28
• All: 5 reference(s)