Septin3^tm1Keng
Targeted Allele Detail

Summary

• Symbol: Septin3^tm1Keng
• Name: septin 3; targeted mutation 1, Mineko Kengaku
• MGI ID: MGI:3715203
• Synonyms: Sept3^-
• Gene: Septin3 Location: Chr15:82153003-82178775 bp, + strand Genetic Position: Chr15, 38.56 cM, cytoband E2
• Alliance: Septin3^tm1Keng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122593
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A partial region of exon 2 and exons 3-5 were replaced with a neomycin resistance cassette flanked by loxP sites. The insertion resulted in the deletion of amino acids 57 to 184. Western blot analysis confirmed absence of protein in brain samples from mutant mice. (J:122593)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Septin3 Mutation: 25 strains or lines available

References

• Original: J:122593 Fujishima K, et al., Targeted disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons. J Neurochem. 2007 Jul;102(1):77-92
• All: 1 reference(s)