Bmp4^tm3.2Blh
Targeted Allele Detail

Summary

• Symbol: Bmp4^tm3.2Blh
• Name: bone morphogenetic protein 4; targeted mutation 3.2, Brigid L Hogan
• MGI ID: MGI:3715255
• Synonyms: Bmp4^delta-lacZ
• Gene: Bmp4 Location: Chr14:46620982-46628126 bp, - strand Genetic Position: Chr14, 23.95 cM
• Alliance: Bmp4^tm3.2Blh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122530
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 3 and 4 were removed by cre-mediated recombination to create a loss of function allele. (J:122530)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmp4 Mutation: 23 strains or lines available

References

• Original: J:122530 Michos O, et al., Reduction of BMP4 activity by gremlin 1 enables ureteric bud outgrowth and GDNF/WNT11 feedback signalling during kidney branching morphogenesis. Development. 2007 Jul;134(13):2397-405
• All: 1 reference(s)