Tg(KRT14-Hr)551Cct
Transgene Detail

Summary

• Symbol: Tg(KRT14-Hr)551Cct
• Name: transgene insertion 551, Catherine C Thompson
• MGI ID: MGI:3715279
• Synonyms: K14-rHr
• Transgene: Tg(KRT14-Hr)551Cct Location: unknown
• Alliance: Tg(KRT14-Hr)551Cct page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Hr)551Cct expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Hr (60563)

  Hr	(MGI:96223)

• Mutation details: A 3.5 kb fragment containing the coding sequence of the rat Hr cDNA was inserted between the human keratin 14 (KRT14) promoter/rabbit beta-globin intron and the KRT14 5' UTR/polyadenylation signal. Hr protein expression is high in the skin in early postnatal development, and remains above wild-type levels as development proceeds. (J:102493)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:102493 Beaudoin GM 3rd, et al., Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14653-8
• All: 1 reference(s)