Pcp2^{tm1(tTA)23Atai}
Targeted Allele Detail

Summary

• Symbol: Pcp2^{tm1(tTA)23Atai}
• Name: Purkinje cell protein 2 (L7); targeted mutation 23, Atsu Aiba
• MGI ID: MGI:3715310
• Synonyms: L7-tTA
• Gene: Pcp2 Location: Chr8:3673371-3675545 bp, - strand Genetic Position: Chr8, 1.92 cM
• Alliance: Pcp2^{tm1(tTA)23Atai} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122536
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutation: Insertion
• Mutation details: 1.0kb of the tetracycline-controlled transactivator (tTA) cDNA fragment from the pTet-Off was inserted into exon 4. (J:122536)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Grm1^tm1Stl/Grm1^tm1Stl Pcp2^tm1(tTA)23Atai/Pcp2^+ Tg(tetO-Grm1)7Atai/?	involves: 129S2/SvPas * C57BL/6N

Phenotypes:

Affected Systems	cx1
show or hide all annotated terms
behavior/neurological	√
behavior/neurological phenotype	N
abnormal behavior	√
abnormal motor coordination/balance	√
abnormal gait	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcp2 Mutation: 35 strains or lines available

Notes

This construct was injected into Grm1^tm1Stl embryos along with Tg

References

• Original: J:122536 Nakao H, et al., Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum. Neurosci Res. 2007 Apr;57(4):538-43
• All: 4 reference(s)