Ank^tm1Kng
Targeted Allele Detail

Summary

• Symbol: Ank^tm1Kng
• Name: progressive ankylosis; targeted mutation 1, David M Kingsley
• MGI ID: MGI:3715330
• Synonyms: Ank^floxP
• Gene: Ank Location: Chr15:27466763-27594995 bp, + strand Genetic Position: Chr15, 10.23 cM
• Alliance: Ank^tm1Kng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122727
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted between exon 3 and 4 and an additional loxP site 5' of exon 3. The floxed neo cassette is subsequently removed by cre-recombination. (J:122727)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ank Mutation: 33 strains or lines available

References

• Original: J:122727 Gurley KA, et al., Mineral formation in joints caused by complete or joint-specific loss of ANK function. J Bone Miner Res. 2006 Aug;21(8):1238-47
• All: 1 reference(s)