Glul^tm1Whla
Targeted Allele Detail

Summary

• Symbol: Glul^tm1Whla
• Name: glutamate-ammonia ligase; targeted mutation 1, Wouter H Lamers
• MGI ID: MGI:3715484
• Synonyms: GS^LacZ
• Gene: Glul Location: Chr1:153775692-153785469 bp, + strand Genetic Position: Chr1, 65.43 cM, cytoband G2
• Alliance: Glul^tm1Whla page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122377
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 through 7 are replaced with a lacZ-neo cassette to create a null allele. RT-PCR was used to confirm the altered transcript. (J:122377)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Glul Mutation: 35 strains or lines available

References

• Original: J:122377 He Y, et al., Glutamine synthetase is essential in early mouse embryogenesis. Dev Dyn. 2007 Jul;236(7):1865-75
• All: 4 reference(s)