Dntt^tm1Fwa
Targeted Allele Detail

Summary

• Symbol: Dntt^tm1Fwa
• Name: deoxynucleotidyltransferase, terminal; targeted mutation 1, Frederick W Alt
• MGI ID: MGI:3715912
• Synonyms: TdT^-
• Gene: Dntt Location: Chr19:41017714-41047964 bp, + strand Genetic Position: Chr19, 34.32 cM
• Alliance: Dntt^tm1Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75921
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was used to eliminate the Dntt promoter and exon 1 by homologous recombination. Terminal deoxynucleotidyl transferase enzymatic activity or transcripts from the mutant allele are not detected in Dntt-null thymocytes by RNA blotting. (J:75921)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dntt Mutation: 34 strains or lines available

Notes

Analyses were performed only in chimeric mice.

References

• Original: J:75921 Komori T, et al., Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. Science. 1993 Aug 27;261(5125):1171-5
• All: 1 reference(s)