Ambra1^{Gt(pGT1.8geo)1Fcec}
Gene trapped Allele Detail

Summary

• Symbol: Ambra1^{Gt(pGT1.8geo)1Fcec}
• Name: autophagy/beclin 1 regulator 1; gene trap 1, Francesco Cecconi
• MGI ID: MGI:3715977
• Synonyms: Ambra1^gt
• Gene: Ambra1 Location: Chr2:91560479-91749194 bp, + strand Genetic Position: Chr2, 50.63 cM
• Alliance: Ambra1^{Gt(pGT1.8geo)1Fcec} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122795
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap insertion was located between the 100 and 113-bp coding exons and disrupted the protein at amino acid position 841, resulting in the deletion of 459 amino acids from the C-terminal end. A fusion transcript was detected and the endogenous protein was absent, as shown by Northern and Western blots, respectively. (J:122795)

Expression

In Mice Carrying this Mutation:	16 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ambra1 Mutation: 118 strains or lines available

References

• Original: J:122795 Maria Fimia G, et al., Ambra1 regulates autophagy and development of the nervous system. Nature. 2007 Jun 28;447(7148):1121-5
• All: 14 reference(s)