Pik3ca^tm1Jdo
Targeted Allele Detail

Summary

• Symbol: Pik3ca^tm1Jdo
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1, Julian Downward
• MGI ID: MGI:3716068
• Synonyms: Pik3ca^RBD
• Gene: Pik3ca Location: Chr3:32451203-32520256 bp, + strand Genetic Position: Chr3, 15.7 cM, cytoband B
• Alliance: Pik3ca^tm1Jdo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122866
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to replace threonine 208 with aspartic acid (T208D) and lysine 227 with alanine (L227A) in exon 3. Cre-mediated recombination was used to remove a floxed neo from the locus. (J:122866)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Pik3ca^tm1Jdo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pik3ca Mutation: 66 strains or lines available

References

• Original: J:122866 Gupta S, et al., Binding of ras to phosphoinositide 3-kinase p110alpha is required for ras-driven tumorigenesis in mice. Cell. 2007 Jun 1;129(5):957-68
• All: 7 reference(s)