Slc7a10^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Slc7a10^tm1Dgen
• Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 10; targeted mutation 1, Deltagen
• MGI ID: MGI:3716074
• Synonyms: Asc1^-, Slc7a10^tm1Xxie
• Gene: Slc7a10 Location: Chr7:34885810-34900539 bp, + strand Genetic Position: Chr7, 21.13 cM, cytoband B1-B5
• Alliance: Slc7a10^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100127
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ and a neo cassette replaced a 115 bp section of sequence encoding amino acids 74 to 112. Brain expression of lacZ, as revealed by X-gal staining, is heterogeneous, being greatest in the brainstem, midbrain, diencephalon and cerebellum and low in forebrain regions; in the spinal cord, expression is restricted to the gray matter. (J:100127)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Slc7a10 Mutation: 26 strains or lines available

References

• Original: J:100127 Xie X, et al., Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice. Brain Res. 2005 Aug 9;1052(2):212-21
• All: 8 reference(s)