Rpgrip1l^tm1Urt
Targeted Allele Detail

Summary

• Symbol: Rpgrip1l^tm1Urt
• Name: Rpgrip1-like; targeted mutation 1, Ulrich Ruther
• MGI ID: MGI:3716208
• Synonyms: Ftm^-
• Gene: Rpgrip1l Location: Chr8:91943658-92039890 bp, - strand Genetic Position: Chr8, 44.29 cM
• Alliance: Rpgrip1l^tm1Urt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122745
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeted mutation was desgned to replace exons 4 and 5 with a PGK-neo cassette. The result was a truncated protein lacking all functional domains except the first coiled-coil domain. (J:122745)

Disease models

Expression

In Structures Affected by this Mutation:

23 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rpgrip1l Mutation: 58 strains or lines available

References

• Original: J:122745 Vierkotten J, et al., Ftm is a novel basal body protein of cilia involved in Shh signalling. Development. 2007 Jul;134(14):2569-77
• All: 13 reference(s)