Tnip3^tm1Rds
Targeted Allele Detail

Summary

• Symbol: Tnip3^tm1Rds
• Name: TNFAIP3 interacting protein 3; targeted mutation 1, Robert D Schreiber
• MGI ID: MGI:3716211
• Synonyms: ABIN-3-null, Tnip3^-
• Gene: Tnip3 Location: Chr6:65567382-65611024 bp, + strand Genetic Position: Chr6, 30.26 cM
• Alliance: Tnip3^tm1Rds page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122758
• Parent Cell Line: MC50 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-5 were replaced by a floxed neo, which was subsequently removed via cre mediated recombination. Absence of protein was confirmed in mutants. (J:122758)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Tnip3^tm1Rds/Tnip3^tm1Rds	involves: 129S6/SvEvTac

Phenotypes:

Affected Systems	hm1
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immune system	N
immune system phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnip3 Mutation: 21 strains or lines available

References

• Original: J:122758 Weaver BK, et al., ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions. Mol Cell Biol. 2007 Jul;27(13):4603-16
• All: 1 reference(s)