Prmt3^Gt(XC265)Byg
Gene trapped Allele Detail

Summary

• Symbol: Prmt3^Gt(XC265)Byg
• Name: protein arginine N-methyltransferase 3; gene trap XC265, BayGenomics
• MGI ID: MGI:3716216
• Synonyms: Prmt3^-
• Gene: Prmt3 Location: Chr7:49428094-49508013 bp, + strand Genetic Position: Chr7, 31.44 cM
• Alliance: Prmt3^Gt(XC265)Byg page

Mutation origin

• Mutant Cell Line: XC265
• Germline Transmission: Earliest citation of germline transmission: J:122768
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: The gene trap vector containing a beta-geo was inserted into intron 14 and resulted in a hypomorphic allele with 5-7% wild-type expression levels in mutants. (J:122768)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XC265	CC178228 ; (MGI Seq Detail)	5' RACE	Chr7:49467797-49498568 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  8 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prmt3 Mutation: 45 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:122768 Swiercz R, et al., Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. J Biol Chem. 2007 Jun 8;282(23):16917-23
• All: 2 reference(s)