Ucn^tm1Abas
Targeted Allele Detail

Summary

• Symbol: Ucn^tm1Abas
• Name: urocortin; targeted mutation 1, Abdul Abou-Samra
• MGI ID: MGI:3716279
• Synonyms: Ucn1-KO, Ucn^tm1Aaz
• Gene: Ucn Location: Chr5:31295407-31296173 bp, - strand Genetic Position: Chr5, 17.11 cM
• Alliance: Ucn^tm1Abas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122730
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to replace the coding sequence after the initiator methionine with a neomycin resistance cassette. In situ hybridization was used to confirm absence of protein expression. (J:122730)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ucn Mutation: 4 strains or lines available

References

• Original: J:122730 Zalutskaya AA, et al., Impaired adaptation to repeated restraint and decreased response to cold in urocortin 1 knockout mice. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E259-63
• All: 1 reference(s)