Usp8^tm1.1Kpk
Targeted Allele Detail

Summary

• Symbol: Usp8^tm1.1Kpk
• Name: ubiquitin specific peptidase 8; targeted mutation 1.1, Klaus-Peter Knobeloch
• MGI ID: MGI:3716283
• Synonyms: Ubpy^fl, Usp8^f
• Gene: Usp8 Location: Chr2:126549280-126601234 bp, + strand Genetic Position: Chr2, 61.76 cM
• Alliance: Usp8^tm1.1Kpk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122732
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 3 and 4. A floxed neo was removed via cre mediated recombination. (J:122732)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp8 Mutation: 52 strains or lines available

References

• Original: J:122732 Niendorf S, et al., Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo. Mol Cell Biol. 2007 Jul;27(13):5029-39
• All: 3 reference(s)