Tg(Rxfp2-cre)5Aia
Transgene Detail

Summary

• Symbol: Tg(Rxfp2-cre)5Aia
• Name: transgene insertion 5, Alexander I Agoulnik
• MGI ID: MGI:3716416
• Synonyms: Rxfp2-iCre, Tg(Rxfp2-iCre)AIA
• Transgene: Tg(Rxfp2-cre)5Aia Location: unknown
• Alliance: Tg(Rxfp2-cre)5Aia page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Rxfp2-cre)5Aia expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Rxfp2

• Mutation details: The transgene comprises the 2429 base pairs that reside immediately upstream of the translation initiation codon of the relaxin/insulin-like family peptide receptor 2 gene, a 1.1-kb DNA fragment containing a consensus Kozak sequence, and coding sequences for the nuclear localization signal of the SV40 large T antigen and for improved Cre recombinase (iCre). Examination of X-gal-stained tissues from male mice bearing both this and the Cre-reporter transgene Gt(ROSA)26^tm1Sor demonstrate Cre expression in the testis, epididymis and cremaster muscle of the adult and in the developing testis, epididymis and gubernacular ligaments at embryonic day 14 (E14). RT-PCR analysis of male embryonic tissues confirmed this expression, though only weakly in the vas deferens. Expression is 20-fold over endogenous levels. (J:122478)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Rxfp2 (species not specified) Summary of all recombinase alleles driven by Rxfp2. Comparative matrix view of recombinase activities

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

The authors report that two founder lines, #1 and #5, exhibit similar expression profiles; data are shown for line 5 only.

References

• Original: J:122478 Feng S, et al., Devlopmental Expression and gene regulations of insulin-like 3 receptor RXFP2 in mouse male reproductive organs. Biol Reprod. 2007 Oct;77(4):671-80
• All: 3 reference(s)