Itgb1bp1^tm1Ref
Targeted Allele Detail

Summary

• Symbol: Itgb1bp1^tm1Ref
• Name: integrin beta 1 binding protein 1; targeted mutation 1, Feinhard Fassler
• MGI ID: MGI:3716519
• Synonyms: Icap1^-
• Gene: Itgb1bp1 Location: Chr12:21317247-21336285 bp, - strand Genetic Position: Chr12, 8.3 cM
• Alliance: Itgb1bp1^tm1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122741
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a lacZ-pgk-neo cassette replaced part of exon 2 and all of exon 3. Northern and Western blot analyses confirmed absence of transcript and protein, respectively, in mutants. (J:122741)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb1bp1 Mutation: 14 strains or lines available

References

• Original: J:122741 Bouvard D, et al., Defective osteoblast function in ICAP-1-deficient mice. Development. 2007 Jul;134(14):2615-25
• All: 4 reference(s)