Trpm8^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Trpm8^tm1Lex
• Name: transient receptor potential cation channel, subfamily M, member 8; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3716553
• Synonyms: Trpm8^-
• Gene: Trpm8 Location: Chr1:88234457-88318909 bp, + strand Genetic Position: Chr1, 44.57 cM
• Alliance: Trpm8^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122956
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The locus was disrupted by replacing exons 1 and 2 with a lacZ/neo cassette. Transcript and protein were not detected in mutant mice. (J:122956)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trpm8 Mutation: 61 strains or lines available

References

• Original: J:122956 Colburn RW, et al., Attenuated cold sensitivity in TRPM8 null mice. Neuron. 2007 May 3;54(3):379-86
• All: 1 reference(s)