Angptl4^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Angptl4^tm1Lex
• Name: angiopoietin-like 4; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3716688
• Synonyms: Angptl4^-
• Gene: Angptl4 Location: Chr17:33993874-34000549 bp, - strand Genetic Position: Chr17, 17.98 cM
• Alliance: Angptl4^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122968
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A targeting vector was designed to replace exons 2 and 3 with a neomycin resistance gene. (J:122968)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angptl4 Mutation: 34 strains or lines available

References

• Original: J:122968 Desai U, et al., Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11766-71
• All: 5 reference(s)