Hsd3b7^tm1Rus
Targeted Allele Detail

Summary

• Symbol: Hsd3b7^tm1Rus
• Name: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7; targeted mutation 1 David W Russell
• MGI ID: MGI:3716711
• Synonyms: Hsd3b7^-
• Gene: Hsd3b7 Location: Chr7:127399830-127402973 bp, + strand Genetic Position: Chr7, 69.74 cM
• Alliance: Hsd3b7^tm1Rus page

Phenotypes of Hsd3b7^tm1Rus/Hsd3b7^tm1Rus mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122973
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-6 were replaced by the ACN cassette encoding neomycin resistance and cre recombinase. Passage through the germline resulted in the deletion of the cassette, leaving a single loxP site. Protein was not detected in immunoblot of mutants. (J:122973)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hsd3b7 Mutation: 18 strains or lines available

Notes

ES cell line = I1C.

References

• Original: J:122973 Shea HC, et al., Inaugural Article: Analysis of HSD3B7 knockout mice reveals that a 3{alpha}-hydroxyl stereochemistry is required for bile acid function. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11526-33
• All: 4 reference(s)