Arc^tm1.1Kuhl
Targeted Allele Detail

Summary

• Symbol: Arc^tm1.1Kuhl
• Name: activity regulated cytoskeletal-associated protein; targeted mutation 1.1, Dietmar Kuhl
• MGI ID: MGI:3716713
• Synonyms: Arc/Arg3.1^-
• Gene: Arc Location: Chr15:74540932-74544419 bp, - strand Genetic Position: Chr15, 34.25 cM
• Alliance: Arc^tm1.1Kuhl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122980
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The entire coding region was flanked by loxP sites. A neomycin resistance cassette and a third loxP site were inserted downstream of the second loxP site. Transient cre expression resulted in the excision of the floxed sequence and the neo cassette. (J:122980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arc Mutation: 28 strains or lines available

References

• Original: J:122980 Plath N, et al., Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron. 2006 Nov 9;52(3):437-44
• All: 13 reference(s)