Tg(Ttr-KLF6)1Fdmn
Transgene Detail

Summary

• Symbol: Tg(Ttr-KLF6)1Fdmn
• Name: transgene insertion 1, Scott Friedman
• MGI ID: MGI:3716726
• Synonyms: TTR1-KLF6
• Transgene: Tg(Ttr-KLF6)1Fdmn Location: unknown
• Alliance: Tg(Ttr-KLF6)1Fdmn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ttr-KLF6)1Fdmn expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KLF6 (1316)

  Klf6	(MGI:1346318)

• Mutation details: The tranthyretin promoter was fused to the human KLF6 cDNA to induce hepatoyte-specific overexpresson that is two- to three-fold above normal levels. Expression is localized to hepatocytes with variable expression in the choroid plexus of the brain at high transgene copy number. In addition to transgenic line 1, lines 4 and 9 were also made. (J:122903)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:122903 Narla G, et al., In vivo regulation of p21 by the Kruppel-like factor 6 tumor-suppressor gene in mouse liver and human hepatocellular carcinoma. Oncogene. 2007 Jun 28;26(30):4428-34
• All: 1 reference(s)