Ar^tm1.1Jdz
Targeted Allele Detail

Summary

• Symbol: Ar^tm1.1Jdz
• Name: androgen receptor; targeted mutation 1.1, Jeffrey D Zajac
• MGI ID: MGI:3716756
• Synonyms: AR^deltaZF2
• Gene: Ar Location: ChrX:97192375-97366821 bp, + strand Genetic Position: ChrX, 42.82 cM
• Alliance: Ar^tm1.1Jdz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123057
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination in the germline resulted in the loss of exon 3, which encodes the second zinc finger of the DNA-binding domain. This deletion has been designed to retain the normal reading frame so that the mutant AR can bind ligand but is unable to bind DNA and regulate target gene transcription. (J:123057)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ar Mutation: 23 strains or lines available

References

• Original: J:123057 Notini AJ, et al., Genomic actions of the androgen receptor are required for normal male sexual differentiation in a mouse model. J Mol Endocrinol. 2005 Dec;35(3):547-55
• All: 13 reference(s)