Shc1^tm4Paw
Targeted Allele Detail

Summary

• Symbol: Shc1^tm4Paw
• Name: src homology 2 domain-containing transforming protein C1; targeted mutation 4, Tony Pawson
• MGI ID: MGI:3716778
• Synonyms: ShcA^deltaSH2, ShcA^R397K
• Gene: Shc1 Location: Chr3:89325858-89337336 bp, + strand Genetic Position: Chr3, 39.11 cM
• Alliance: Shc1^tm4Paw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122927
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was used to insert cDNA containing an R397K substitution with a single Flag-pA epitope tag and a floxed neo into exon 3, replacing the exon 4 of the locus. (J:122927)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shc1 Mutation: 66 strains or lines available

References

• Original: J:122927 Hardy WR, et al., Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science. 2007 Jul 13;317(5835):251-6
• All: 3 reference(s)