Shc1^tm6Paw
Targeted Allele Detail

Summary

• Symbol: Shc1^tm6Paw
• Name: src homology 2 domain-containing transforming protein C1; targeted mutation 6, Tony Pawson
• MGI ID: MGI:3716780
• Synonyms: ShcA^313F
• Gene: Shc1 Location: Chr3:89325858-89337336 bp, + strand Genetic Position: Chr3, 39.11 cM
• Alliance: Shc1^tm6Paw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122927
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was used to insert cDNA containing the Y313F mutation with a single Flag-pA epitope tag and a floxed neo into exon 3, replacing the exon 4 of the locus. (J:122927)

Tumor Data

List all tumor models in MMHCdb carrying Shc1^tm6Paw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shc1 Mutation: 66 strains or lines available

References

• Original: J:122927 Hardy WR, et al., Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science. 2007 Jul 13;317(5835):251-6
• All: 4 reference(s)