Shc1^tm9Paw
Targeted Allele Detail

Summary

• Symbol: Shc1^tm9Paw
• Name: src homology 2 domain-containing transforming protein C1; targeted mutation 9, Tony Pawson
• MGI ID: MGI:3716783
• Synonyms: ShcA^flx
• Gene: Shc1 Location: Chr3:89325858-89337336 bp, + strand Genetic Position: Chr3, 39.11 cM
• Alliance: Shc1^tm9Paw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122927
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1. The wild-type cDNA with a 3xFlag epitope tag-pA cassette was inserted into in exon 3. A neomycin resistance gene was inserted downstream of the cassette and loxP site. (J:122927)

Tumor Data

List all tumor models in MMHCdb carrying Shc1^tm9Paw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Shc1 Mutation: 66 strains or lines available

References

• Original: J:122927 Hardy WR, et al., Combinatorial ShcA docking interactions support diversity in tissue morphogenesis. Science. 2007 Jul 13;317(5835):251-6
• All: 4 reference(s)