Prex1^tm1Hcew
Targeted Allele Detail

Summary

• Symbol: Prex1^tm1Hcew
• Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1; targeted mutation 1, Heidi C E Welch
• MGI ID: MGI:3716859
• Synonyms: P-Rex1^-
• Gene: Prex1 Location: Chr2:166408265-166555752 bp, - strand Genetic Position: Chr2, 87.09 cM
• Alliance: Prex1^tm1Hcew page

Limb clasping in Prex1^tm1Hcew/Prex1^tm1Hcew Prex2^{Gt(RRD186)Byg}/Prex2^{Gt(RRD186)Byg} mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:102214
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 5, which encodes catalytic residues in the DH domain, was replaced with a neomycin resistance cassette and a translational stop codon. Northern blot confirmed absence of transcript in mutant mice. (J:102214)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prex1 Mutation: 70 strains or lines available

References

• Original: J:102214 Welch HC, et al., P-Rex1 regulates neutrophil function. Curr Biol. 2005 Oct 25;15(20):1867-73
• All: 11 reference(s)