Sox17^tm1Sjm
Targeted Allele Detail

Summary

• Symbol: Sox17^tm1Sjm
• Name: SRY (sex determining region Y)-box 17; targeted mutation 1, Sean J Morrison
• MGI ID: MGI:3717118
• Synonyms: Sox17^GFP
• Gene: Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM
• Alliance: Sox17^tm1Sjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123050
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace the coding region (involving exons 4 and 5) in frame with the Sox17 start codon, with EGFP and an FRT-flanked neomycin resistance cassette. No Sox17 mRNA is detected by RT-PCR. EGFP is expressed in cells that normally express Sox17. (J:123050)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox17 Mutation: 29 strains or lines available

References

• Original: J:123050 Kim I, et al., Sox17 dependence distingushes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell. 2007 Aug 10;130(3):470-83
• All: 19 reference(s)