Sox17^tm2Sjm
Targeted Allele Detail

Summary

• Symbol: Sox17^tm2Sjm
• Name: SRY (sex determining region Y)-box 17; targeted mutation 2, Sean J Morrison
• MGI ID: MGI:3717121
• Synonyms: Sox17^cKO, Sox17^fl
• Gene: Sox17 Location: Chr1:4561154-4567577 bp, - strand Genetic Position: Chr1, 1.65 cM
• Alliance: Sox17^tm2Sjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123050
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted on either side of the exon 3-5 region of the Sox17 gene. Mice homozygous for this allele are viable and fertile and do not display any gross physical or behavioral abnormalities. When crossed with a Cre recombinase-expressing strain, this strain is useful in eliminating tissue-specific expression of the gene. (J:123050)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox17 Mutation: 29 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Intracranial Aneurysm J:234137.

References

• Original: J:123050 Kim I, et al., Sox17 dependence distingushes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell. 2007 Aug 10;130(3):470-83
• All: 17 reference(s)