St14^Gt(XM184)Byg
Gene trapped Allele Detail

Summary

• Symbol: St14^Gt(XM184)Byg
• Name: suppression of tumorigenicity 14 (colon carcinoma); gene trap XM184, BayGenomics
• MGI ID: MGI:3717152
• Synonyms: ST14^hypo
• Gene: St14 Location: Chr9:31000698-31043149 bp, - strand Genetic Position: Chr9, 16.61 cM
• Alliance: St14^Gt(XM184)Byg page

Mutation origin

• Mutant Cell Line: XM184
• Germline Transmission: Earliest citation of germline transmission: J:108567
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: Insertion of a genetrap vector placed into intron 1 a pGT0pfs construct containing the intron from the engrailed 2 gene upstream of the gene encoding beta-galactosidase/neomycin-phosphotransferase fusion protein. This allele expresses 100-fold reduction in mRNA levels and is a hypomorphic allele. (J:108567)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XM184	CC325291 ; (MGI Seq Detail)	5' RACE	unknown
  * GRCm39; (strand of gene trap mutagenesis)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any St14 Mutation: 45 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:108567 List K, et al., Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis. Am J Pathol. 2006 May;168(5):1513-25
• All: 13 reference(s)