Tg(Eno2-APOE_i4)1Rabr
Transgene Detail

Summary

• Symbol: Tg(Eno2-APOE_i4)1Rabr
• Name: transgene insertion 1, Jacob Raber
• MGI ID: MGI:3717178
• Synonyms: E4, (NSE)-apoE4, Tg(Eno2-APOE*4)1Rabr
• Transgene: Tg(Eno2-APOE_i4)1Rabr Location: unknown
• Alliance: Tg(Eno2-APOE_i4)1Rabr page

Transgene origin

• Strain of Origin: ICR

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-APOE_i4)1Rabr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

• Mutation details: A construct containing the first exon, first intron, first 6 bases of the second exon of the human APOE gene, and the third intron followed by the APOE cDNA was placed downstream of the rat gamma neuronal enolase 2 promoter. Downstream of the cDNA was the noncoding region of the fourth exon and 112 bp of the 3'-flanking sequence of APOE containing the polyadenylation signal. The construct was injected into one-cell ICR embryos. (J:100975)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100975 Raber J, et al., Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10914-9
• All: 14 reference(s)