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Tg(Eno2-APOE_i4)1Rabr
Transgene Detail
Summary
Symbol: Tg(Eno2-APOE_i4)1Rabr
Name: transgene insertion 1, Jacob Raber
MGI ID: MGI:3717178
Synonyms: E4, (NSE)-apoE4, Tg(Eno2-APOE*4)1Rabr
Transgene: Tg(Eno2-APOE_i4)1Rabr  Location: unknown  
Alliance: Tg(Eno2-APOE_i4)1Rabr page
Transgene
origin
Strain of Origin:  ICR
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Eno2-APOE_i4)1Rabr expresses 1 gene
 
Mutation detailsA construct containing the first exon, first intron, first 6 bases of the second exon of the human APOE gene, and the third intron followed by the APOE cDNA was placed downstream of the rat gamma neuronal enolase 2 promoter. Downstream of the cDNA was the noncoding region of the fourth exon and 112 bp of the 3'-flanking sequence of APOE containing the polyadenylation signal. The construct was injected into one-cell ICR embryos. (J:100975)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:100975 Raber J, et al., Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10914-9
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory