Tg(Eno2-APOE_i3)1Rabr
Transgene Detail

Summary

• Symbol: Tg(Eno2-APOE_i3)1Rabr
• Name: transgene insertion 1, Jacob Raber
• MGI ID: MGI:3717179
• Synonyms: E3, (NSE)-apoE3, Tg(Eno2-APOE*3)1Rabr
• Transgene: Tg(Eno2-APOE_i3)1Rabr Location: unknown
• Alliance: Tg(Eno2-APOE_i3)1Rabr page

Transgene origin

• Strain of Origin: ICR

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Eno2-APOE_i3)1Rabr expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOE (348)

  Apoe	(MGI:88057)

• Mutation details: A construct containing the first exon, first intron, and first 6 bases of the second exon of the human APOE gene, followed by the APOE cDNA was placed downstream of the rat gamma neuronal enolase 2 promoter. Downstream of the cDNA was the noncoding region of the fourth exon and 112 bp of the 3'-flanking sequence of APOE containing the polyadenylation signal. The construct was injected into one-cell ICR embryos. (J:100975)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Apoe^tm1Unc/Apoe^tm1Unc Tg(Eno2-APOE_i3)1Rabr/0	involves: 129P2/OlaHsd * C57BL/6J * ICR
cx2	Apoe^tm1Unc/Apoe^tm1Unc Tg(Eno2-APOE_i3)1Rabr/0	involves: 129P2/OlaHsd * ICR

Phenotypes:

Affected Systems	cx1	cx2
show or hide all annotated terms
behavior/neurological	√	N
behavior/neurological phenotype	N	N
abnormal spatial learning	√
enhanced coordination	√
nervous system	√
abnormal nervous system physiology	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:100975 Raber J, et al., Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10914-9
• All: 12 reference(s)