Tg(Ckm-PTPN1)45Bbk
Transgene Detail

Summary

• Symbol: Tg(Ckm-PTPN1)45Bbk
• Name: transgene insertion 45, Barbara B Kahn
• MGI ID: MGI:3717234
• Synonyms: MCK-hPTP1B
• Transgene: Tg(Ckm-PTPN1)45Bbk Location: unknown
• Alliance: Tg(Ckm-PTPN1)45Bbk page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-PTPN1)45Bbk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTPN1 (5770)

  Ptpn1

  (MGI:97805)

• Mutation details: This transgene expresses the cDNA of the human isoform of protein tyrosine phosphatase 1B (PTPN1) from the mouse muscle creatine kinase promoter. Transgenic mice overexpress this construct 1.8 fold in skeletal muscle. No overexpression was detected in heart. (J:122895)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic mice have impaired insulin-signaling and insulin-stimulated glucose uptake into skeletal muscle, resulting in impaired whole-body glucose homeostasis.

References

• Original: J:122895 Zabolotny JM, et al., Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action. J Biol Chem. 2004 Jun 4;279(23):24844-51
• All: 2 reference(s)