Tg(Ckm-PTPRF)13Bbk
Transgene Detail

Summary

• Symbol: Tg(Ckm-PTPRF)13Bbk
• Name: transgene insertion 13, Barbara B Kahn
• MGI ID: MGI:3717241
• Synonyms: MCK-hLAR
• Transgene: Tg(Ckm-PTPRF)13Bbk Location: unknown
• Alliance: Tg(Ckm-PTPRF)13Bbk page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-PTPRF)13Bbk expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PTPRF (5792)

  Ptprf

  (MGI:102695)

• Mutation details: This transgene consists of the cDNA of the human isoform of the leukocyte antigen-related protein tyrosine phosphatase (LAR or PTPRF), with expression driven from the mouse muscle creatine kinase promoter. Transgenic mice overexpress the construct 2-fold in skeletal muscle and at a very low level in cardiac tissue. (J:123133)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Transgenic mice have impaired insulin-signaling and insulin-stimulated glucose uptake into skeletal muscle, resulting in impaired whole-body glucose homeostasis.

References

• Original: J:123133 Zabolotny JM, et al., Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance. Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5187-92
• All: 3 reference(s)