Tg(Ckm-DGAT2)10Far
Transgene Detail

Summary

• Symbol: Tg(Ckm-DGAT2)10Far
• Name: transgene insertion 10, Bob Farese
• MGI ID: MGI:3717406
• Synonyms: MCK-DGAT2
• Transgene: Tg(Ckm-DGAT2)10Far Location: unknown
• Alliance: Tg(Ckm-DGAT2)10Far page

Transgene origin

• Strain of Origin: C57BL/6NHsd

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-DGAT2)10Far expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DGAT2 (84649)

  Dgat2

  (MGI:1915050)

• Mutation details: The targeting construct was designed with 4 kb of the mouse muscle creatine kinase (MCK) promoter sequence placed upstream of a 1.2 kb human acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) cDNA sequence, followed by a 2.2 kb human growth hormone minigene (providing the polyA signal). The transgene was microinjected into C57BL/6NHsd fertilized eggs and the resulting transgenic offspring were bred to C57BL/6NHsd. Founder line 10 mice were established. (J:129495)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:129495 Levin MC, et al., Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1772-81
• All: 1 reference(s)