Tg(Thy1-APP)4Vln
Transgene Detail

Summary

• Symbol: Tg(Thy1-APP)4Vln
• Name: transgene insertion 4, Fred Van Leuven
• MGI ID: MGI:3717568
• Synonyms: APP/Wt, APP/Wt/4
• Transgene: Tg(Thy1-APP)4Vln Location: unknown
• Alliance: Tg(Thy1-APP)4Vln page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-APP)4Vln expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APP (351)

  App	(MGI:88059)

• Mutation details: cDNA encoding the human wild-type amyloid precursor protein (695 isoform) was cloned into the pTSC vector in the mouse Thy1 gene. The linearized minigene was injected into prenuclear embryos from FVB/N females. Human APP protein is expressed in hippocampus, parietal and frontal cortices at 2-5 times the endogenous APP levels, at lower levels in olfactory bulb and thalamus, and at very low levels in the cerebellum. (J:53800)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:53800 Moechars D, et al., Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem. 1999 Mar 5;274(10):6483-92
• All: 3 reference(s)