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Tg(Thy1-APPLon)2Vln
Transgene Detail
Summary
Symbol: Tg(Thy1-APPLon)2Vln
Name: transgene insertion 2, Fred Van Leuven
MGI ID: MGI:3717572
Synonyms: APP/Ld/2, APP/V717I, Tg(Thy1-APP*Lon)2Vln, Tg(Thy1-APP*V642I)2Vln
Transgene: Tg(Thy1-APPLon)2Vln  Location: unknown  
Alliance: Tg(Thy1-APPLon)2Vln page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-APPLon)2Vln expresses 1 gene
 
Mutation detailscDNA encoding the human London (V642I) amyloid precursor protein variant (695 isoform) was cloned into the pTSC vector in the mouse Thy1 gene. The linearized minigene was injected into prenuclear embryos from FVB/N females. Human mutant APP protein is expressed in hippocampus, parietal and frontal cortices at 2-5 times the endogenous APP levels, at lower levels in olfactory bulb and thalamus, and at very low levels in the cerebellum. (J:53800)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:53800 Moechars D, et al., Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem. 1999 Mar 5;274(10):6483-92
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory