Tg(Thy1-APPLon)2Vln
Transgene Detail
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Symbol: |
Tg(Thy1-APPLon)2Vln |
Name: |
transgene insertion 2, Fred Van Leuven |
MGI ID: |
MGI:3717572 |
Synonyms: |
APP/Ld/2, APP/V717I, Tg(Thy1-APP*Lon)2Vln, Tg(Thy1-APP*V642I)2Vln |
Transgene: |
Tg(Thy1-APPLon)2Vln Location: unknown
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Alliance: |
Tg(Thy1-APPLon)2Vln page
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Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Thy1-APPLon)2Vln expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
APP (351) |
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The gene encodes for the London mutation. |
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Mutation details: cDNA encoding the human London (V642I) amyloid precursor protein variant (695 isoform) was cloned into the pTSC vector in the mouse Thy1 gene. The linearized minigene was injected into prenuclear embryos from FVB/N females. Human mutant APP protein is expressed in hippocampus, parietal and frontal cortices at 2-5 times the endogenous APP levels, at lower levels in olfactory bulb and thalamus, and at very low levels in the cerebellum.
(J:53800)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:53800 Moechars D, et al., Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem. 1999 Mar 5;274(10):6483-92 |
All: |
32 reference(s) |
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