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Tg(Thy1-APPSw)1Vln
Transgene Detail
Summary
Symbol: Tg(Thy1-APPSw)1Vln
Name: transgene insertion 1, Fred Van Leuven
MGI ID: MGI:3717574
Synonyms: APP/Sw/1, Tg(Thy1-APP*K670N*M671L)1Vln, Tg(Thy1-APP*Swe)1Vln
Transgene: Tg(Thy1-APPSw)1Vln  Location: unknown  
Alliance: Tg(Thy1-APPSw)1Vln page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Thy1-APPSw)1Vln expresses 1 gene
 
Mutation detailscDNA encoding the human Swedish (K670N,M671L) amyloid precursor protein variant (770 isoform) was cloned into the pTSC vector in the mouse Thy1 gene. The linearized minigene was injected into prenuclear embryos from FVB/N females. Human mutant APP protein is expressed in hippocampus, parietal and frontal cortices at 2-5 times the endogenous APP levels, at lower levels in olfactory bulb and thalamus, and at very low levels in the cerebellum. (J:53800)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:53800 Moechars D, et al., Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain. J Biol Chem. 1999 Mar 5;274(10):6483-92
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory